ArticleAuthors: Le, Thi Thu Huong; Gerardo, M. Casañola-Martin; Facundo, Pérez-Giménez; Yovani, Marrero-Ponce; Advisor: Matilde, Merino-Sanjuán; Concepción, Abad; Humberto, González-Díaz (2015)
The ubiquitin–proteasome pathway (UPP) plays
an important role in the degradation of cellular proteins and
regulation of different cellular processes that include cell
cycle control, proliferation, differentiation, and apoptosis. In
this sense, the disruption of proteasome activity leads to dif-ferent pathological states linked to clinical disorders such
as inflammation, neurodegeneration, and cancer. The use of
UPP inhibitors is one of the proposed approaches to manage
these alterations. On other hand, the ChEMBL database con-tains >5,000 experimental outcomes for >2,000 compounds
tested as possible proteasome inhibitors using a large number
of pharmacological assay protocol... 
