Browsing by Subject A549

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  • 4. Bui Thanh Tung.QT.pdf.jpg
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  • Authors: Pham, Thi Minh Hue; Le, Phuong Linh; Nguyen, Van Lam; Nguyen, Thanh Hai; Ho, Anh Son; Nguyen, Linh Toan; Bui, Thanh Tung (2015-03)

  • A PEGylated liposomal formulation of doxoburicin has been developed and evaluated with the purpose of reducing toxicity and improving the tumor-targeting efficacy of doxorubicin.PEGylated liposomal doxorubicin was prepared by the lipid film hydration technique using hydrogenated soybean phosphatidylcholine (HSPC) combined with cholesterol and DSPE-PEG . Biological activity and toxicity were tested on A549 and HT 29 cancer cell lines by the MTT method. As the result, the obtained PEGylated liposomal doxorubicin using the lipid film hydration method had an entrapment efficiency of the drug more than 95%. The formulated liposomes were found to be relatively uniform in size (167.8± 3.6 nm...

Browsing by Subject A549

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 1 of 1
  • 4. Bui Thanh Tung.QT.pdf.jpg
  • Article


  • Authors: Pham, Thi Minh Hue; Le, Phuong Linh; Nguyen, Van Lam; Nguyen, Thanh Hai; Ho, Anh Son; Nguyen, Linh Toan; Bui, Thanh Tung (2015-03)

  • A PEGylated liposomal formulation of doxoburicin has been developed and evaluated with the purpose of reducing toxicity and improving the tumor-targeting efficacy of doxorubicin.PEGylated liposomal doxorubicin was prepared by the lipid film hydration technique using hydrogenated soybean phosphatidylcholine (HSPC) combined with cholesterol and DSPE-PEG . Biological activity and toxicity were tested on A549 and HT 29 cancer cell lines by the MTT method. As the result, the obtained PEGylated liposomal doxorubicin using the lipid film hydration method had an entrapment efficiency of the drug more than 95%. The formulated liposomes were found to be relatively uniform in size (167.8± 3.6 nm...