Browsing by Subject xanthine oxidase (OX)

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  • Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhiobitors.pdf.jpg
  • Article


  • Authors: V. Kemami Wangun, Hilaire; Hartl, Albert; Trinh Tam, Kiet; Hertweck, Christian (2006-05-09)

  • Arthritis is a general term for severe inflammatory processes in joints or joint tissue. Nonsteroidal anti-inflammatory drugs , such as diclofenac and indomethacin, have emerged the most commonly used anti- inflammatory agents for the therapy of rheumatoid arthritis. Many of these drugs target cyclooxygenases (COX), which catalyze the first two steps in the biosynthesis of the prostaglandins from the substrate arachidonic acid. In this context, the selective inhibition of enzyme subtypes, COX-1 and COX-2, has become an important goal. In contrast to rheumatoid arthritis, gouty arthritis is mediated by the crystallisation of uric acid (UA) in the joints. Gout can be treated with drugs ...

Browsing by Subject xanthine oxidase (OX)

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 1 of 1
  • Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhiobitors.pdf.jpg
  • Article


  • Authors: V. Kemami Wangun, Hilaire; Hartl, Albert; Trinh Tam, Kiet; Hertweck, Christian (2006-05-09)

  • Arthritis is a general term for severe inflammatory processes in joints or joint tissue. Nonsteroidal anti-inflammatory drugs , such as diclofenac and indomethacin, have emerged the most commonly used anti- inflammatory agents for the therapy of rheumatoid arthritis. Many of these drugs target cyclooxygenases (COX), which catalyze the first two steps in the biosynthesis of the prostaglandins from the substrate arachidonic acid. In this context, the selective inhibition of enzyme subtypes, COX-1 and COX-2, has become an important goal. In contrast to rheumatoid arthritis, gouty arthritis is mediated by the crystallisation of uric acid (UA) in the joints. Gout can be treated with drugs ...