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  • Article


  • Authors: Nguyen, Thanh Hai; Bui, Thanh Tung (2015)

  • Doxorubicin hydrochloride is an antitumor antibiotic derived from anthracyclines. It has had limited use because of its dose-related cardiotoxicity and myelosuppression. Liposomes have been used as a vehicle for administration of pharmaceutical drugs because of their ability to improve the delivery of drugs to tumors, increase therapeutic efficacy, and decrease toxicity to normal cells. The aim of this study is to prepare a new liposomal dxorubicin on a large -scale and evaluate its antitumor activity in vivo. Liposomes were formed using the hydration of a thin lipid film method, and doxorubicin was loaded through a pH gradient technique. Based on TEM images, large lamellar vesicles (LUV) were formed, with sizes of 95 ± 10 nm, having a polydispersity index of 0.138 ±...

  • Article


  • Authors: Nguyễn, Hoàng Long (2014)

  • Nghiên cứu trên 1.200 đối tượng trung niên (40 - 59 tuổi), thuộc 4 xã thuần nông của huyện Đông Sơn tỉnh Thanh Hóa bằng phương pháp khám lâm sàng, đo huyết áp và xét nghiệm đường máu lúc đói, nhằm mục tiêu: xác định tỷ lệ hiện mắc và một số yếu tố liên quan đến tăng huyết áp, tăng đường huyết. Kết quả cho thấy: Tỷ lệ đối tượng có tăng huyết áp là 19,7%. Kết quả nghiên cứu cũng xác định được mối liên quan giữa tỷ lệ tăng huyết áp và nhóm tuổi, giới tính, nghề nghiệp, chỉ số BMI, số đo vòng mông với các OR từ 1,84 - 2,24, p<0,05. Tỷ lệ đối tượng tăng đường huyết là 16,6%. Kết quả cho thấy xu hướng liên quan thuận giữa tăng đường huyết với tăng tuổi, nghề ít vận động thể lực, nhóm không nghèo, chỉ số BMI cao hơn bình thường, số đo vòng eo và tỷ số vòng eo/số đo vòng mông ...

  • Article


  • Authors: Nguyen, Hoang Long (2015)

  • Background Patient satisfaction is an important component of quality in healthcare delivery. To inform the expansion of Methadone Maintenance Treatment (MMT) services in Vietnam, we exam-ined the satisfaction of patients with regards to different services delivery models and identi-fied its associated factors. Methods We interviewed 1,016MMT patients at 5 clinics in Hanoi and Nam Dinh province. Themodi-fied SATIS instrument, a 10-item scale, was used tomeasure three dimensions:“Services quality and convenience”,“Health workers’capacity and responsiveness”and“Inter-profes-sional care”. Results The average score was high across three SATIS dimensions. However, only one third of patients completely satisfied with general health services and treatment outcomes. Older age, highe...

  • Article


  • Authors: Nguyen, Hoang Long (2015)

  • Background:Smoking cessation treatment service is concerned to be a critical element in methadone maintenance treatment (MMT) in order to diminish the effect of smoke on health outcomes. To implement the smoking cessation services in Vietnam, we examined the stages of change to quit and determined associated factors among MMT patients. Methods:We conducted a cross-sectional survey with 1016 MMT patients in five clinics in Hanoi and Nam Dinh province, of those, 932 (91.7 %) were ever-smokers. Patients were classified into four groups:“pre-contemplation,” “contemplation,”“preparation,” and“action and maintenance” by using the transtheoretical model. Multivariate logistic regression was applied to determine the associated factor for intention and action to quit smoking. Results...

  • Article


  • Authors: Nguyen, Hoang Long (2016)

  • Background:The rapid expansion of methadone maintenance treatment (MMT) services has significantly improved health status and quality of life of patients. However, little is known about its impacts on addiction-related stigma and associated factors. Methods:A cross-sectional survey was conducted in 2013 in Vietnam’s capital, Hanoi, and Nam Dinh province among 1016 methadone maintenance patients; 26.6 % at provincial AIDS centers (PAC) and 73.4 % at district health centers (DHC), respectively. Drug addiction history and related stigma, health status, MMT-related covariates, and sociodemographic characteristics were interviewed. Results:More than one-sixth of the sample reported experiencing felt or enacted stigma, including Blame or Judgement (17.2 %), Shame (19.9 %), or Othe...

  • Article


  • Authors: Nguyen, Hoang Long (2014)

  • Cost effective threshold is essential in an economic evaluation. This study aimed to estimate the willingness to pay (WTP) for a Quality Adjusted Life Year (QALY) in Bavi district, Hanoi 2014 and examine some associated factors. Method: 360 respondents from Bavi district, Hanoi were interviewed. Dichotomous bidding choice followed by open-ended question was employed in this study. Results:Mean of willingness to pay for a Quality Adjusted life year in Bavi, Hanoi, 2014 ranged from 13,934,010 to 20,737,620 VND (~667.3 – 993.1$ US). The WTP per QALY for worse health states are higher than those for better states. Gender, utility of health status assessed by respondents and monthly household income were determined as associated factors. Conclusions: The WTP/QALY values...

  • Article


  • Authors: Nguyen, Hoang Long (2015)

  • Background:Utility estimates are important health outcomes for economic evaluation of care and treatment interventions for patients with HIV/AIDS. We conducted a systematic review and meta-analysis of utility measurements to examine the performance of preference-based instruments, estimate health utility of patients with HIV/AIDS by disease stages, and investigate changes in their health utility over the course of antiretroviral treatment. Methods:We searched PubMed/Medline, Cochrane Database of Systematic Review, NHS Economic Evaluation Database and Web of Science for English-language peer-reviewed papers published during 2000–2013. We selected 49 studies that used 3 direct and 6 indirect preference based instruments to make a total of 218 utility measurements. Random effect...

  • Article


  • Authors: Nguyen, Hoang Long (2015)

  • Background:Integrating and decentralizing services are essential to increase the accessibility and provide comprehensive care for methadone patients. Moreover, they assure the sustainability of a HIV/AIDS prevention program by reducing the implementation cost. This study aimed to measure the preference of patients enrolling in a MMT program for integrated and decentralized MMT clinics and then further examine related factors. Methods:A cross-sectional study was conducted among 510 patients receiving methadone at 3 clinics in Hanoi. Structured questionnaires were used to collect data about the preference for integrated and decentralized MMT services. Covariates including socio-economic status; health-related quality of life (using EQ-5D-5 L instrument) and HIV status; history ...

  • Article


  • Authors: Vu, Duc Loi (2014)

  • The search for newer histone deacetylase (HDAC) inhibitors has attracted a great deal of interest of medicinal chemists worldwide, especially after the first HDAC inhibitor (Zolinza ® , widely known as SAHA or Suberoylanilide hy-droxamic acid) was approved by the FDA for the treatment of T-cell lymphoma in 2006. As a continuity of our ongoing research in this area, we designed and synthesized a series of 5-aryl-1,3,4-thiadiazole-based hydroxamic acids as ana-logues of SAHA and evaluated their biological activities. Most of the compounds in this series, e.g.compounds with 5-aryl moiety being 2-furfuryl (5a), 5-bromofuran-2-yl (5b), 5-methylfuran-2-yl (5c), thiophen-2-yl (5d), 5-methylthiophen-2-yl (5f) and pyridyl (5g-i), were found to have potent anticancer cytotoxicity with I...