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  • Authors: Vu, Duc Loi (2014)

  • The search for newer histone deacetylase (HDAC) inhibitors has attracted a great deal of interest of medicinal chemists worldwide, especially after the first HDAC inhibitor (Zolinza ® , widely known as SAHA or Suberoylanilide hy-droxamic acid) was approved by the FDA for the treatment of T-cell lymphoma in 2006. As a continuity of our ongoing research in this area, we designed and synthesized a series of 5-aryl-1,3,4-thiadiazole-based hydroxamic acids as ana-logues of SAHA and evaluated their biological activities. Most of the compounds in this series, e.g.compounds with 5-aryl moiety being 2-furfuryl (5a), 5-bromofuran-2-yl (5b), 5-methylfuran-2-yl (5c), thiophen-2-yl (5d), 5-methylthiophen-2-yl (5f) and pyridyl (5g-i), were found to have potent anticancer cytotoxicity with I...

  • Article


  • Authors: Nguyen, Thanh Hai; Le, Tuan Anh; Duong, Thi Ly Huong; Nguyen, Huu Tung; Vu, Duc Loi; Dang, Thu Kim; Bui, Thanh Tung (2015)

  • Objective: To investigated the protective potential of ethanol extracts of Scutellaria baicalensis (S. baicalensis) against lipopolysaccharide (LPS)-induced liver injury. Methods:Dried roots of S. baicalensiswere extracted with ethanol and concentrated to yield a dry residue. Mice were administered 200 mg/kg of the ethanol extracts orally once daily for one week. Animals were subsequently administered a single dose of LPS(5 mg/kg of body weight, intraperitoneal injection). Both protein and mRNAlevels of cytokines, such as tumor necrosis factor alpha, interleukin-1β, and interleukin-6 in liver tissues were evaluated by ELISA assay and quantitative PCR. Cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB protein levels in liver tissues were analyzed ...

  • Article


  • Authors: Bui, Thanh Tung; Nguyen, Hai Thanh; Duong, Thi Ly Huong; Le, Thi Thu Huong; Vu, Duc Loi; Nguyen, Huu Tung (2015)

  • Tetracera scandens L. (Dilleniaceae) is a genus of flowering plants of the Dilleniaceae family. It has been reported that Tetracera scandens L. content hight amout of flavonoids. From the ethanol extract of leaves of Tetracera scandens L, we have been isolated six known flavonoids compounds. Their structures were identified as quercetin-3-O-L-rhamnoside (1), genistein (2), quercetin (3), quercetin 3-O-β-D-glucuronide (4), kaempferol (5) and quercetin-3-O-α-L-arabinofuranoside (6) on the basis of spectroscopic data and by comparing their physicochemical and spectral data with those published in literatures

  • Article


  • Authors: Bui, Thanh Tung; Nguyen, Thanh Hai; Pham, Thi Minh Hue; Le, Thi Thu Huong; Duong, Thi Ly Huong; Vu, Duc Loi (2015)

  • Objective: To investigate the protective potential of ethanolic extracts of Tetracera scandens L. ( T. scandens ) against CCl induced oxidative stress in liver tissues. Methods: Dried leaf powder of T. scandens was extracted with ethanol and concentrated to yield a dry residue. Rats were administered with 100 mg/kg of ethanolic extracts orally once daily for one week. Animals were subsequently administered with a single dose of CCl 4 (1 mL/kg body weight, intraperitoneal injection). Various assays, such as serum levels of alanine aminotransferase, aspartate aminotransferase, lipid peroxidation, protein oxidation (carbonyl protein group), tumor necrosis factor alpha, catalase, superoxide dismutase, and glutathione peroxidase, were used to assess damage caused by CCl and the protectiv...

  • Article


  • Authors: Nguyen, Thanh Hai; Pham, Thi Minh Hue; Vu, Duc Loi; Bui, Thanh Tung (2016)

  • We investigate the effects of Coenzyme Q10 (CoQ10) supplementation on methamphetamine (METH)-induced neurotoxicity in the mouse brain. We used 30 mice divided into three groups containing 10 animals each: a control group, a brain injury group treated with METH and a group treated with METH+CoQ10. Various assays, such as protein thiol group, glutathione total, lipid peroxidation, catalase, superoxide dismutase and glutathione peroxidase, were used to assess the damage caused by METH and the protective effects of CoQ10 on brain tissues. The METH-induced brain injury significantly increased lipid peroxidation and decreased the level of the thiol group, the glutathione total and the activity of brain antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase)...

  • Article


  • Authors: Vu, Duc Loi; Bui, Thanh Tung; Nguyen, Huu Tung; Nguyen, Thanh Hai; Nguyen, Thuc Thu Huong; Nguyen, Tien Vung (2015)

  • The roots of Aconitum Carmichaeli Debx. is recognized as a medicinal plant by its anti-inflammatory and analgesic effects. Our phytochemical investigation of the roots led to the isolation of three alkaloids including delcosine (1), fuziline (2), and karacoline (3). Their structures were identified on the basis of NMR, MS, IR spectroscopic analysis and comparison with the published NMR data. Compound 1 was isolated for the first time from this plant

  • Article


  • Authors: Vu, Duc Loi; Bui, Thanh Tung; Nguyen, Thanh Hai; Nguyen, Tien Vung (2015)

  • Two flavonol glycosides: 5,7,3 ' -trimethoxyquercetin -3-O-β-D-fructofuranoside (1), 7,4′-O-dimethylluteolin 5-O-[α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside] (2) and one fatty acid ester (Z)-3-hydroxypentan-2-yl-10-aminooctacos-9-enoate (3) were isolated from the leaves of Aconitum carmichaeli Debx growing in Ha Giang province, Vietnam. Their structures were elucidatedby spectroscopic methods, including IR, MS and NMR. This is first time these compounds were isolated from leaves of A. carmichaeli Debx.

  • Article


  • Authors: Vu, Duc Loi; Bui, Thanh Tung; Nguyen, Tien Vung (2016)

  • Nerium oleander L. is an evergreen shrub in the dogbane family Apocynaceae and planted throughout the tropical region. It has cardiotonic, antioxidant, anti-inflammatory and anticancer activities.Nerium oleanderL. has high amount of cardiac glycoside and flavonoids compounds. From methanol extract of flowers of Nerium oleanderL. grown in vietnam, it has been isolated four compounds. Their structures were identified as (1) D 16 -Dehydroadynerigenin, (2) D 16 -Digitoxigenin, (3) Quercetin and (4) Kaempferol on the basis of spectroscopic data and by comparing their physicochemical and spectral data with those published studies. The effect of fraction HF2, which containing compound 1 and 2 on heart function was examined, revealing potent positive inotropic effect on isolated...