Authors: Bui, Thanh Tung; Nguyen, Hai Thanh; Le, Thi Thu Huong; Rodriguez-Bies, Elisabet; Navas, Plácido; Sanchez, Virginia Motilva; López-Lluch, Guillermo (2015)
BACKGROUND: Oxidative stress has been considered one of the causes of aging. For this reason, treatments based on antioxidants or those capable of increasing endogenous antioxidant activity have been taken into consideration to delay aging or age-related disease progression.
In this paper, we determine if resveratrol and exercise have similar effect on the antioxidant capacity of different organs in old mice.
Resveratrol (6 months) and/or exercise (1.5 months) was administered to old mice. Markers of oxidative stress (lipid peroxidation and glutathione) and activities and levels of antioxidant enzymes (SOD, catalase, glutathione peroxidase, glutathione reductase and transferase and thioredoxin reductases, NADH cytochrome B5-reductase and NAD(P)H-quinone accepto...