Please use this identifier to cite or link to this item: http://repository.vnu.edu.vn/handle/VNU_123/26660
Title: Ginsenoside F2 induces apoptosis accompanied by protective autophagy in breast cancer stem cells
Authors: Mai Thi Trang
Moon, JeongYong
Song, YeonWoo
Pham Quoc Viet
Pham Van Phuc
Keywords: Apoptosis;Autophagy;Breast cancer stem cells;Ginsenoside F2
Issue Date: 2012
Publisher: ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
Citation: ISIKNOWLEDGE
Abstract: Ginsenoside F2 (F2) was assessed for its antiproliferative activity against breast cancer stem cells (CSCs). F2 induced apoptosis in breast CSCs by activating the intrinsic apoptotic pathway and mitochondrial dys-function. Concomitantly, F2 induced the formation of acidic vesicular organelles, recruitment of GFP-LC3-II to autophagosomes, and elevation of Atg-7 levels, suggesting that F2 initiates an autophagic progres-sion in breast CSCs. Treatment with an inhibitor of autophagy enhanced F2-induced cell death. Our find-ings provide new insights into the anti-cancer activity of F2 and may contribute to the rational use and pharmacological study of F2.
Description: TNS06838 ; CANCER LETTERS Volume: 321 Issue: 2 Pages: 144-153 Published: AUG 28 2012
URI: http://repository.vnu.edu.vn/handle/VNU_123/26660
http://www.sciencedirect.com/science/article/pii/S0304383512001000
ISSN: 0304-3835
1872-7980
Appears in Collections:Bài báo của ĐHQGHN trong Web of Science

Files in This Item:
Thumbnail

  • File : TNS06838.pdf
  • Description : 
  • Size : 1.24 MB
  • Format : Adobe PDF


  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.