Please use this identifier to cite or link to this item: http://repository.vnu.edu.vn/handle/VNU_123/26824
Title: Effects of Solvents and Crystallization Conditions on the Polymorphic Behaviors and Dissolution Rates of Valsartan
Authors: Tran, Thao Truong-Dinh
Tran, Phuong Ha-Lien
Park, Jun-Bom
Keywords: Valsartan;Crystallization condition;Structural behavior;Solvent type;Polymor-phism,;Dissolution rate
Issue Date: 2012
Publisher: PHARMACEUTICAL SOC KOREA, 1489-3 SUHCHO-DONG, SUHCHO-KU, SEOUL 137-071, SOUTH KOREA
Citation: ISIKNOWLEDGE
Abstract: For the quality evaluation of raw materials, the influence of various types of solvents on the polymorphic crystallization behaviors and dissolution rates of two sources of valsartan (VAL) from China and India was investigated. Samples were prepared by recrystallization from water or organic solvents, such as acetonitrile, acetone and ethanol, using methods with and without heating. Recrystallization behaviors were characterized by differential scanning calo-rimetry (DSC) and powder X-ray diffraction (PXRD). Scanning electron microscopy (SEM) was also used to observe the morphology of samples. The dissolution rate of recrystallized samples in water was evaluated and compared to the original VAL sample. There were significant dif-ferences in morphology, crystal structure and dissolution rate among the samples recrystal-lized using organic solvents. VAL was transformed into another polymorphic form by the solvents and recrystallization conditions. These physical properties of VAL also differed between the two sources of VAL. Thus, the physicochemical differences of raw materials should be carefully considered in early dosage formulation approaches.
Description: TNS06852; ARCHIVES OF PHARMACAL RESEARCH Volume: 35 Issue: 7 Pages: 1223-1230 Published: JUL 2012
URI: http://repository.vnu.edu.vn/handle/VNU_123/26824
http://link.springer.com/article/10.1007%2Fs12272-012-0713-7
ISSN: 0253-6269
1976-3786
Appears in Collections:Bài báo của ĐHQGHN trong Web of Science

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