Please use this identifier to cite or link to this item: http://repository.vnu.edu.vn/handle/VNU_123/27082
Title: Geranyl Dihydrochalcones from Artocarpus altilis and Their Antiausteric Activity
Authors: Mai Thanh Thi Nguyen
Nhan Trung Nguyen
Khang Duy Huu Nguyen
Keywords: PREFERENTIAL CYTOTOXIC ACTIVITY
NUTRIENT-DEPRIVED CONDITION
CANCER-CELL-LINES
PANCREATIC-CANCER
Issue Date: 2014
Publisher: GEORG THIEME VERLAG KG, RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
Citation: ISIKNOWLEDGE
Abstract: Human pancreatic cancer cell lines have remark-able tolerance to nutrition starvation, which en-ables them to survive under a tumor microenvir-onment. The search for agents that preferentially inhibit the survival of cancer cells under low nu-trient conditions is a novel antiausterity strategy in anticancer drug discovery. In this study, the methanolic extract of the leaves ofArtocarpus al-tilis showed 100% preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions at a concen-tration of 50µg/mL. Further investigation of this extract led to the isolation of eight new gerany-lated dihydrochalcones named sakenins A–H(1– 8) together with four known compounds (9–12). Among them, sakenins F (6)and H(8) were iden-tified as potent preferentially cytotoxic candi-dates with PC50values of 8.0µM and 11.1 µM, re-spectively.
Description: PLANTA MEDICA Volume: 80 Issue: 2-3 Pages: 193-200 Published: FEB 2014
URI: http://repository.vnu.edu.vn/handle/VNU_123/27082
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