Please use this identifier to cite or link to this item: http://repository.vnu.edu.vn/handle/VNU_123/27084
Title: Analysis of knockout mutants reveals non-redundant functions of poly(ADP-ribose)polymerase isoforms in Arabidopsis
Authors: Tohge, Takayuki
Pham, Phuong Anh
Wahl, Vanessa
Keywords: Arabidopsis thaliana;Central carbon metabolism;Central carbon metabolism;Root;Poly(ADP-ribose)polymerase;Metabolite profiling
Issue Date: 2015
Publisher: Đại học Quốc gia Hà Nội
Citation: ISIKNOWLEDGE
Abstract: The enzyme poly(ADP-ribose)polymerase (PARP) has a dual function being involved both in the poly(ADPribosyl) ation and being a constituent of the NAD? salvage pathway. To date most studies, both in plant and non-plant systems, have focused on the signaling role of PARP in poly(ADP-ribosyl)ation rather than any role that can be ascribed to its metabolic function. In order to address this question we here used a combination of expression, transcript and protein localization studies of all three PARP isoforms of Arabidopsis alongside physiological analysis of the corresponding mutants. Our analyses indicated that whilst all isoforms of PARP were localized to the nucleus they are also present in non-nuclear locations with parp1 and parp3 also localised in the cytosol, and parp2 also present in the mitochondria.
Description: PLANT MOLECULAR BIOLOGY Volume: 89 Issue: 4-5 Pages: 319-338 Published: NOV 2015 ; TNS05557
URI: http://repository.vnu.edu.vn/handle/VNU_123/27084
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