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Title: Biomedical and environmental applications of magnetic nanoparticles
Authors: Dai Lam, Tran
Van Hong, Le
Hoai Linh, Pham
Thi My Nhung, Hoang
Thi Quy, Nguyen
Thien Tai, Luong
Phuong Thu, Ha
Xuan Phuc, Nguyen
Keywords: Heavy ion removal;Hyperthermia;Magnetic heating;Magnetic nanoparticles
Issue Date: 2010
Publisher: H. : ĐHQGHN
Abstract: This paper presents an overview of syntheses and applications of magnetic nanoparticles (MNPs) at the Institute of Materials Science, Vietnam Academy of Science and Technology. Three families of oxide MNPs, magnetite, manganite and spinel ferrite materials, were prepared in various ways: coprecipitation, sol-gel and high energy mechanical milling. Basic properties of MNPs were characterized by Vibrating Sample Magnetometer (VSM) and Physical Properties Measurement Systems (PPMS). As for biomedical application, the aim was to design a novel multifunctional, nanosized magnetofluorescent water-dispersible Fe3O4-curcumin conjugate, and its ability to label, target and treat tumor cells was described. The conjugate possesses a magnetic nano Fe3O4 core, chitosan (CS) or Oleic acid (OL) as an outer shell and entrapped curcumin (Cur), serving the dual function of naturally autofluorescent dye as well as antitumor model drug. Fe3O4-Cur conjugate exhibited a high loading cellular uptake with the help of a macrophage, which was clearly visualized dually by Fluorescence Microscope and Laser Scanning Confocal Microscope (LSCM), as well as by magnetization measurement (PPMS). A preliminary magnetic resonance imaging (MRI) study also showed a clear contrast enhancement by using the conjugate. As for the environmental aspect, the use of magnetite MNPs for the removal of heavy toxic metals, such as Arsenic (As) and Lead (Pb), from contaminated water was studied. © 2010 Vietnam Academy of Science & Technology.
Description: Advances in Natural Sciences: Nanoscience and Nanotechnology Volume 1, Issue 4, December 2010, Article number 045013
ISSN: 20436262
Appears in Collections:Bài báo của ĐHQGHN trong Scopus

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