Please use this identifier to cite or link to this item: http://repository.vnu.edu.vn/handle/VNU_123/32287
Title: Novel Multifunctional Biocompatible Gelatin-Oleic Acid Conjugate: Self-Assembled Nanoparticles for Drug Delivery
Authors: Tran, Phuong Ha-Lien
Tran, Thao Truong-Dinh
Vo, Van Van
Keywords: Gelatin-OA Conjugate (GOC);Self-Assembled Nanoparticles;Targeted Drug Delivery;Paclitaxel;Folic Acid (FA);Protein Conjugation
Issue Date: 2013
Publisher: AMER SCIENTIFIC PUBLISHERS, 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
Citation: ISIKNOWLEDGE
Abstract: In this work, a novel, biocompatible conjugates of gelatin and oleic acid (GOC) were synthesized by a novel aqueous solvent-based method that overcame challenges of completely contrary solubility between gelatin and oleic acid (OA). The GO nanoparticles (GONs) and Paclitaxel encapsulated nanoparticles (PTX-GON) were prepared by self-assembly in water. These nanoparticles (NPs) were then conjugated with folic acid (FA) for targeting cervical cancer cells (Hela cells) and were characterized for their various physicochemical and pharmaceutical properties. Fourier transform infrared spectroscopy (FT-IR) and 1 H NMR studies indicated the successful synthesis of GOC which showed low critical aggre-gation concentration in water (0.015 mg/ml). All NPs were stable in human blood serum and their mean diameters were below 300 nm suitable for passive targeting. Powder X-ray diffraction (PXRD) diffractograms showed the reduction in drug crystallinity and hence, leading to the solubility enhancement of PTX. The release of PTX from both PTX-GON and FA conjugated PTX-GON (PTX-FA-GON) was controlled for a long time. The cytotoxicity results demonstrated great advantages of PTX-FA-GON and PTX-GON over the conventional dosage form of pacliaxel (Taxol ® . These results, there-fore, indicate that GOC is a promising material to prepare drug encapsulated NP as a controlled delivery system and PTX-FA-GON is a potential targeted delivery system for cancer therapy.
Description: JOURNAL OF BIOMEDICAL NANOTECHNOLOGY Volume: 9 Issue: 8 Pages: 1416-1431 Published: AUG 2013 ; TNS07217
URI: https://www.ncbi.nlm.nih.gov/pubmed/23926810
http://repository.vnu.edu.vn/handle/VNU_123/32287
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