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  • Authors: Luu, Manh Quynh; Nguyen, Minh Hieu; Nguyen, Hoang Nam (2015)

  • In this study, the fast DNA diagnostics was successfully developed using high fluorescent Mn doped ZnS nanoparticles and NH2-modified SiO2 coated Fe3O4 nanoparticles in a sandwich structure. In one end of the sandwich structure, we employed NH2-modified SiO2 coated Fe3O4 nanoparticles as a docking matrix. A so-called capture probe oligonucleotide chain, that specifically identifies the target DNA, linked to the docking magnetic particles. In the other end, other oligonucleotide chain – named detector probe – contacted with the signaling semiconductor particles. The complementary hybridization of the detector probe – target – capture probe formed the sandwich configuration that attached the fluorescent particles to the docking matrix. This configuration was used to detect DNA of Epst...