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  • Interaction of Vietnamese Medicinal Plant Extracts with Recombinantly Expressed Human Neurokinin-1 Receptor

    • Authors: Dinh, Doan Long; Pham, Thi Hong Nhung; Hoang, Thi My Nhung; Trinh, Tat Cuong; Nguyen, Thi Hong Van; Vo, Thi Thuong Lan; Pham, Thanh Huyen; Lundstrom, Kenneth (2015)

  • A primary functional receptor screening assay was performed to examine the effects of methanolic extracts from ten Vietnamese medicinal plants on the human neurokinin-1 receptor expressed from Semliki Forest virus vectors in Chinese hamster ovary cells. Extracts from Piper nigrum, Stephania cambodica and Styphnolobium japonicum were found to exert inhibition on agonist-induced human neurokinin-1 receptor activity. Secondary assays and high performance liquid chromatography of the lead compounds addressed a possible association between pharmacological responses and these chemical compounds. Strong inhibition of human neurokinin-1 receptor was observed for extracts revealing the highest...

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Browsing by Subject Fabaceae

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 2 of 2
  • #4-DDL_2015_QT.pdf.jpg
  • Article

  • Interaction of Vietnamese Medicinal Plant Extracts with Recombinantly Expressed Human Neurokinin-1 Receptor

    • Authors: Dinh, Doan Long; Pham, Thi Hong Nhung; Hoang, Thi My Nhung; Trinh, Tat Cuong; Nguyen, Thi Hong Van; Vo, Thi Thuong Lan; Pham, Thanh Huyen; Lundstrom, Kenneth (2015)

  • A primary functional receptor screening assay was performed to examine the effects of methanolic extracts from ten Vietnamese medicinal plants on the human neurokinin-1 receptor expressed from Semliki Forest virus vectors in Chinese hamster ovary cells. Extracts from Piper nigrum, Stephania cambodica and Styphnolobium japonicum were found to exert inhibition on agonist-induced human neurokinin-1 receptor activity. Secondary assays and high performance liquid chromatography of the lead compounds addressed a possible association between pharmacological responses and these chemical compounds. Strong inhibition of human neurokinin-1 receptor was observed for extracts revealing the highest...