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  • Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst

    • Authors: Lưu, Văn Bôi; Phạm, Hoài Thu; Nguyễn, Vũ Quang Thành; Doãn, Thu Hồng; Nguyễn, Bích Ngọc; Vũ, Thị Huệ; Mạc, Đình Hùng (2013)

  • Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditions (solvent, reaction time, temperature and catalyst…). The research results showed that in toluene, at a temperature of 800C, with acid L-pipecolic as catalyst, the yield of pichromenes reached 82% after 24h. The structure of the products was determined by the data of 1H-NMR and 13C-NMR spectroscopy. .

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Browsing by Author Doãn, Thu Hồng

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 1 of 1
  • document(7).pdf.jpg
  • Article

  • Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst

    • Authors: Lưu, Văn Bôi; Phạm, Hoài Thu; Nguyễn, Vũ Quang Thành; Doãn, Thu Hồng; Nguyễn, Bích Ngọc; Vũ, Thị Huệ; Mạc, Đình Hùng (2013)

  • Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditions (solvent, reaction time, temperature and catalyst…). The research results showed that in toluene, at a temperature of 800C, with acid L-pipecolic as catalyst, the yield of pichromenes reached 82% after 24h. The structure of the products was determined by the data of 1H-NMR and 13C-NMR spectroscopy. .