ArticleAuthors: Lưu, Văn Bôi; Phạm, Hoài Thu; Nguyễn, Vũ Quang Thành; Doãn, Thu Hồng; Nguyễn, Bích Ngọc; Vũ, Thị Huệ; Mạc, Đình Hùng (2013)
Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditions (solvent, reaction time, temperature and catalyst…). The research results showed that in toluene, at a temperature of 800C, with acid L-pipecolic as catalyst, the yield of pichromenes reached 82% after 24h. The structure of the products was determined by the data of 1H-NMR and 13C-NMR spectroscopy. . 
