Browsing by Subject G-protein coupled receptor

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  • Multi-scale-simulations-of-membrane-proteins-The-case-of-bitter-taste-receptors_2017_Journal-of-Science-Advanced-Materials-and-Devices.pdf.jpg
  • Article


  • Authors: Suku, Eda; Fierro, Fabrizio; Giorgetti, Alejandro; Alfonso-Prieto, Mercedes; Carloni, Paolo (2017)

  • Human bitter taste receptors (hTAS2Rs) are the second largest group of chemosensory G-protein coupled receptors (25 members). hTAS2Rs are expressed in many tissues (e.g. tongue, gastrointestinal tract, respiratory system, brain, etc.), performing a variety of functions, from bitter taste perception to hormone secretion and bronchodilation. Due to the lack of experimental structural information, computations are currently the methods of choice to get insights into ligandereceptor interactions. Here we review our efforts at predicting the binding pose of agonists to hTAS2Rs, using state-of-the-art bioinformatics ap-proaches followed by hybrid Molecular Mechanics/Coarse-Grained (MM/CG) s...

Browsing by Subject G-protein coupled receptor

Jump to: 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
or enter first few letters:  
Showing results 1 to 1 of 1
  • Multi-scale-simulations-of-membrane-proteins-The-case-of-bitter-taste-receptors_2017_Journal-of-Science-Advanced-Materials-and-Devices.pdf.jpg
  • Article


  • Authors: Suku, Eda; Fierro, Fabrizio; Giorgetti, Alejandro; Alfonso-Prieto, Mercedes; Carloni, Paolo (2017)

  • Human bitter taste receptors (hTAS2Rs) are the second largest group of chemosensory G-protein coupled receptors (25 members). hTAS2Rs are expressed in many tissues (e.g. tongue, gastrointestinal tract, respiratory system, brain, etc.), performing a variety of functions, from bitter taste perception to hormone secretion and bronchodilation. Due to the lack of experimental structural information, computations are currently the methods of choice to get insights into ligandereceptor interactions. Here we review our efforts at predicting the binding pose of agonists to hTAS2Rs, using state-of-the-art bioinformatics ap-proaches followed by hybrid Molecular Mechanics/Coarse-Grained (MM/CG) s...