Medical and Pharmaceutical Sciences : [103]

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Collection's Items (Sorted by Submit Date in Descending order): 1 to 20 of 103
  • Validation of a High-Performance Liquid Chromatographic Method with Diod Array Detection for the Quantification of Citral and Formulation of Insect Repellent Cream from Lemongrass Oil.pdf.jpg
  • Article


  • Authors: Nguyen, Thi Thanh Binh; Bui, Thanh Tung; Nguyen, Thi Mai; Nguyen, Thi Hue (2020)

  • Lemongrass oil derived from some species of grasses in the family of Poaceae (particularly Cymbopogon citratus) posses a highly effective insect repellent potential. In Vietnam, this product is widely commercially available but its quality is not strictly controlled. From a formulator's perspective, lemongrass essential oil is not suitable for direct application on the skin because high concentrations of citral, major chemical constituent of this oil, may cause local irritation. In addition, this compound is volatile, resulting in a short repellent effect. Contributing to solve these problems, a high-performance liquid chromatography with diode array detection was developed for the si...

  • Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract.pdf.jpg
  • Article


  • Authors: Tran, Thi Hai Yen; Hoang, Thi Hien; Vu, Thi Thu Giang (2020)

  • Rutin is a natural flavonoid that has many effects on human health and beauty. However, rutin has low solubility and bioavailability. Niosomes are drug delivery system that enhance drug permeation of drug through the skin. Aloe is widly used in cosmetic preparations due to its antiaging, moisturizing and essential skin nutrients. Therefore, the aim of study is preparation of nano niosomes, loaded with rutin and aloe gel extraction (rutin-aloe niosomes) by thin film hydration method. Rutin niosomes was reduced size by ultrasonic method. The size and distribution of vesicles were determined by dynamic light scattering method. Drug content in niosomal suspension was determined by UV-Vis...

  • Malignant Hyperthermia and Gene Polymorphisms Related to Inhaled Anesthesia Drug Response.pdf.jpg
  • Article


  • Authors: Vu, Thi Thu Hang; Nguyen, Thi Thuy Mau; Nguyen, Tran Thuy; Le, Ngoc Thanh; Pham, Thi Hong Nhung; Dinh, Doan Long; Nguyen, Thi Thu Hoai; Vu, Thi Thom (2020)

  • Malignant hyperthermia (MH) is a clinical response happened to patient who is sensitive with inhaled anesthesia drug that could cause suddently death. Many previous studies showed that malignant hyperthermia strongly related to genetic background of patients including RYR1, CACNA1S or STAC3 gene polymorphisms. With the development of high technology such as next generation sequencing, scientists found that 37 to 86 percents of MH cases had RYR1 mutations and approximately 1 percent of those had CACNA1S mutations. Gene analysis testing was recommended to apply for patient with MH medical history or MH patient’s family relations.

  • Knowledge, Attitude of Parents’s and Quality of Life in Children with Chronic Kidney Disease.pdf.jpg
  • Article


  • Authors: Phan, Van Dem; Le, Thi Thu Hoai (2020)

  • To identify the percentage of parents having the correct knowledge of caring their children and evaluable quality of life in children with chronic kidney diseases. Subject and method: descriptive cross sectional study and evaluated the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales of 115 children with chronic kidney diseases (CKD) and their parents who treated at Department of Pediatric of Bach Mai hospital. Results: the parents’ correct knowledge about CKD was persistant and relapse (90,4% and 89,4%). The sourse of information parents’s from medical staffs was 48,2% and 23% from social networking. Over 50% of parents thought that knowledge getting from medical...

  • Jak-Stat Signaling Pathway Related Gene Expressions and Blood Biochemical indicators in Acute Promyelocytic Leukemia.pdf.jpg
  • Article


  • Authors: Bui, Kieu Trang; Nguyen, Thi Xuan (2020)

  • Acute promyelocytic leukemia (APL) is a type of acute leukemia, which has the highest death rate among blood cancers and caused by a specific (15; 17) chromosomal translocation, resulting in a fusion gene PML/RARα. Klotho gene plays a role in preventing aging, inflammation and cancer. CTLA4, PD1 and LAG3 are immunosuppressive receptors located on surface of T cells and considered as a negative regulation of immune response. These genes regulate immune cell activity through several signalling moleculars such as STATs and NF-κB. In this study, to additionally determine the difference between APL and other leukemia, we performed experiments to measure mRNA expression of above genes by us...

  • Henoch-Schonlein Purpura in Children at Department of Pediatric, Bach Mai Hospital.pdf.jpg
  • Article


  • Authors: Pham, Van Dem (2020)

  • Henoch-Schonlein Purpura (HSP) is one of the most common vasculitis disease in children. The main symtomps are rash, arthritis, abdominal pain, and kidney disease. In particular, kidney involvement is important to predict long-term outcomes of disease. Aim: This study aimed to describe the epidemic characteristics, clinical manifestations and some laboratory findings of HSP in children. Subjects of study: We studied 50 patients diagnosed with HSP at Deparment of Pediatrics, Bach Mai hospital from 2017 to 2018. Results: The mean age was 9,1 ± 3,2 years, with the ratio of male to female to be 1,17:1. HSP has seasonal characteristics, it was more common in the spring (43.4%) and the win...

  • Evaluation of the Usage of Erythropoietin in Patients with End-Stage Chronic Kidney Disease Dialysis Cycle in Hanoi Nephrology Hospital.pdf.jpg
  • Article


  • Authors: Do, Thi Hoa; Nguyen, Thi Tuyet Trinh; Nguyen, Thi Lien Huong; Phan, Tung Linh (2020)

  • Treatment and control of anemia plays an important role in improving the quality and effectiveness of artificial kidney. The study was conducted on 61 patients who met the selection and were not included in the excluded criteria group. Collecting data from medical records using retrospective, descriptive, vertical follow-up method for 6 months. Data were processed using Microsoft Excel Office 2010 and R. The results showed that patients used both EPO alpha and EPO beta simultaneously. Rate of usage’s EPO beta accounted for 23%, alpha EPO was 77%. Lyophilized form (EPO alpha) is most commonly used. Starting from T3, Hb. averages treat. There were no abnormalities in blood pressure, whi...

  • Cytotoxicity and Antioxidant Effects of Celastrus hindsii Benth. Leaf Extract.pdf.jpg
  • Article


  • Authors: Bui, Thi Thanh Duyen; Dang, Kim Thu; Vu, Manh Hung; Bui, Thanh Tung (2020)

  • Celastrus hindsii Benth et Hook. is known as a herbal medicine for the treatment of cancer. In this study we evaluated the cytotoxic and antioxidant effects of Celastrus hindsii Benth et Hook. leaf extract. Samples of Celastrus hindsii were extracted with 90 % ethanol and subsequently fractionated with n-hexane, ethyl acetate (EtOAc) and n-butanol (n-BuOH) solvents. To evaluate the cytotoxic effect, we performed MTT (3- (4,5 dimethylthiazol-2 - yl) - 2,5 - diphenyltetrazolium) assay on the three cell lines human liver Hep G2 (HB - 8065TM), lung LU-1 (HTB - 57TM), breast MCF-7 (HTB - 22TM). The antioxidant effect was evaluated by screening DPPH (2,2-diphenyl-1-picryhydrazyl) free radi...

  • Formulating Methyl Salicylate Microemulsion.pdf.jpg
  • Article


  • Authors: Tran, Thi Hai Yen; Hoang, Thuc Oanh; Vu, Thi Thu Giang (2020)

  • Methyl salicylate (MS) is an active pharmaceutical ingredient of NSAIDS group, often used in topical dosage forms such as ointments, gels, patches, etc. to treat and relieve muscle and joint diseases. Microemulsion is the potential drug delivery systems because of various advantages: oil droplet size is in range of several nanometers, good appearance, transparent, simple methods of preparation and simple application in manufacturing. The purpose of the study is to formulate a phase diagram to identify the area of methyl salicylate microemulsion formation and formulate MS microemulsion 1% and 5%. The water titration method is used to build the phase diagram. MS microemulsions were eval...

  • Evaluation of the Effect of Dissolution Conditions on the Release Profiles of Felodipine from the Extended Release Push-Pull Osmotic Tablets.pdf.jpg
  • Article


  • Authors: Vu, Thi Thanh Huyen; Nguyen, Thanh Hai; Pham, Thi Minh Hue (2020)

  • The bilayered push–pull osmotic tablets of 5 mg felodipine were prepared by the double compression method, then the core tablets were coated with cellulose acetate as a semipermeable membrane. One releasing orifice was drilled by laser on the drug side of tablets. The osmotic tablets of felodipine containing low molecular weight PEO (200.000) as the primary component in the drug layer, high molecular weight PEO (5.000.000) as a swelling agent in the push layer and natri chloride as osmotic agent in both drug and push layers which were semi-permeable membrane coated with a weight gain of 8.5 % and the drilled release orifice of 0.8 mm. The influence of dissolution conditions on the rele...

  • Comparing Acetylcholinesterase and Butyrylcholinesterase Inhibition Effect of Total Extract and Fractions with Alcaloid-Rich Extract of Huperzia Serrata (Thunb.) Trevis..pdf.jpg
  • Article


  • Authors: Nguyen, Thi Thu Hoai; Nguyen, Thuy Duong; Bui, Thanh Tung; Dao, Thi Vui; Dang, Kim Thu (2020)

  • Herbal extract, rich with natural compounds, has been used for medicinal purpose such as treating neurological disorders such as cognitive defection for a long period of time, often without significant adverse effects. We compared AChE and BuChE – inhibition effect of total extracts and fractions of Huperzia serrata (Thunb.) Trevis. with alcaloid-rich extract. Our samples were subjected under supersonic extraction with ethanol 50o as solvent and fractionally extracted with nhexane, EtOAc and n-butanol, respectively; alcaloid-rich extract was collected simutaneously. Ellman’s method was used to assay AChE and BuChE inhibition activity. Results: Alcaloid-rich extraction proved to be the...

  • Anatomy of the Middle Cerebral Artery and some related arteries on 256 MSCT .pdf.jpg
  • Article


  • Authors: Nguyễn, Tuấn Sơn; Ngô, Xuân Khoa; Nguyễn, Quốc Dũng; Đào, Đình Thi (2019)

  • Mục tiêu: Xác định tỷ lệ hiện ảnh và kích thước của động mạch (ĐM) não giữa và một số ĐM liên quan bằng hình ảnh phim chụp cắt lớp vi tính 256 dãy. Phương pháp: nghiên cứu mô tả cắt ngang hồi cứu với phương pháp chọn mẫu thuận tiện cỡ mẫu 261. Kết quả: Khả năng hiện ảnh các đoạn của ĐM não giữa là 100%; ĐM thông sau là 76,4; ĐM cảnh trong đoạn trong sọ ngoài màng cứng là 100%%; Đường kính trung bình (ĐKTB), chiều dài trung bình (CDTB) của các ĐM lần lượt là (mm): M1T 3,25±0,43 và 19,98±6,10; M1 P 3,26±0,46 và 19,68±6,28; M2T trái 2,10±0,48 và 22,85±13,18; M2T phải 2,09±0,49 và 23,42±11,89; M2D trái 2,48±0,49 và 31,73-16,36; M2D phải 2,55±0,49 và 29,11±15,31. PCoA T 1,29±0,63 và 11,87±...

  • Direct costs for treatment of venous thromboembolism complication 90-day after surgery .pdf.jpg
  • Article


  • Authors: Bùi, Mỹ Hạnh; Dương, Tuấn Đức; Trần, Tiến Hưng; Nguyễn, Hữu Chính; Kiều, Thị Tuyết Mai (2019)

  • Study object: Describe the direct treatment costs due to venous thromboembolism complications 90 days after surgery by using national health insurance reimbursement database. Patients: 824,947 adult patients who underwent major surgeries were enrolled from January 1, 2017 to September 31, 2018. Method: Study was conducted by using cross-sectional descriptive design. Patients were considered VTE case if they had a diagnostic code up to 90 days after the first surgery, thus 1472 were diagnosed as having VTE after surgery. The study using propensity score matching method shows that there were 913 pairs of patients with the same propensity score included in analysis. Results: The rate of ...

  • Analysis of cots for children treatment pneumonia in Bach Mai Ha Noi hospital from 102018 to 32019 .pdf.jpg
  • Article


  • Authors: Bùi, Thị Xuân; Phạm, Văn Đếm; Hoàng, Văn Hùng (2019)

  • Nghiên cứu chi phí trực tiếp điều trị viêm phổi trẻ em điều trị ở bệnh viện Bạch Mai từ tháng 10/2018 đến tháng 3/2019 cho thấy chi phí giường bệnh chiếm tỷ lệ cao nhất, sau đó mới đến chi phí thuốc và chi phí cho chẩn đoán.Trong chi phí thuốc thì kháng sinh là cao nhất, trong chi phí chẩn đoán thì chi phí xét nghiệm chiếm chủ yếu. Chi phí điều trị có mối liên quan rõ rệt đến số ngày điều trị bên cạnh đó các yếu tố mức độ bệnh hay có bệnh mắc kèm chỉ ảnh hưởng khi xem xét riêng lẻ. Sự hỗ trợ của bảo hiểm y tế có thể lên tới hơn 70% tổng chi phí trực tiếp. Kết quả nghiên cứu cho thấy chi phí điều trị ở Việt Nam thấp hơn một số nước trong khu vực, sự phân bổ chí phí tương đồng với một s...

  • Diagnosis of Left Ventricular Hypertrophy Based on Electrocardiogram Signal and Fuzzy Logic .pdf.jpg
  • Article


  • Authors: Trần, Như Chí; Nguyễn, Thị Thanh Vân; Lê, Văn Chiều (2019)

  • Chỉ số Sokolow – Lyon dùng để xác định bệnh phì đại thất trái từ Điện tâm đồ (ECG) là một chỉ số giới hạn cứng. Bởi vậy, biểu hiện lâm sàng của bệnh có thể bị bỏ qua khi giá trị tính được là lân cận ngưỡng. Một vài nghiên cứu đã đề xuất kết hợp nhiều chỉ số khác nhau để cải tiến chất lượng chẩn đoán bệnh. Tuy nhiên, quá trình kiểm tra và chẩn đoán sẽ mất nhiều thời gian do cần thu thập dữ liệu lớn. Để giải quyết vấn đề này, báo cáo đề xuất một phương pháp chẩn đoán lâm sàng bệnh phì đại thất trái sử dụng kỹ thuật Logic mờ kết hợp xử lý tín hiệu số. Phương pháp đề xuất chủ yếu sử dụng chỉ số Sokolow – Lyon (SV1+RV5/V6 ≥ 35 mm) để phát hiện những dấu hiệu bất thường của tín hiệu ECG như...

  • APOC3-rs2854116 polymorphism related to hypercholesterolemia in primary school children in Hanoi .pdf.jpg
  • Article


  • Authors: Nguyễn, Thị Hồng Hạnh; Trần, Quang Bình (2019)

  • Gen Apolipoprotein C3 (APOC3) giữ vai trò quan trọng trong việc điều chỉnh nồng độ lipid của cơ thể. Nghiên cứu này được tiến hành nhằm đánh giá mối liên quan của đa hình APOC3-rs2854116 với rối loạn lipid máu (RLLM) ở trẻ tiểu học tại Hà Nội. Một nghiên cứu bệnh - chứng được tiến hành trên 161 trẻ mắc RLLM và 406 trẻ bình thường từ 6 - 11 tuổi. Kiểu gen được xác định bằng phương pháp đa hình chiều dài đoạn cắt giới hạn (PCR-RFLP). Kết quả cho thấy, ở nhóm bệnh, có sự khác nhau về các chỉ số lipid máu giữa những trẻ mang kiểu gen khác nhau tại đa hình APOC3-rs2854116. Trẻ mang kiểu gen G/G có nồng độ cholesterol tổng số (TC), triglyceride (TG) và lipoprotein tỉ trọng thấp (Low Density...

  • Double Burden of Nutrition and some Eating Habits Characteristics of Preschool Children in Nam Hong Commune, Dong Anh district, Hanoi, 2018 .pdf.jpg
  • Article


  • Authors: Lê, Thị Tuyết; Nguyễn, Thị Trung Thu; Ngô, Thị Thu Hoài; Nguyễn, Thị Lan Hương; Lê, Thị Thùy Dung; Đỗ, Nam Khánh (2019)

  • Nghiên cứu nhằm cung cấp bằng chứng về gánh nặng kép dinh dưỡng (bao gồm cả suy dinh dưỡng (SDD) và thừa cân, béo phì (TC, BP)) cũng như ảnh hưởng của thói quen ăn uống đến tình trạng dinh dưỡng của trẻ mầm non xã Nam Hồng, huyện Đông Anh, Hà Nội - nơi đang trong quá trình đô thị hóa. Đối tượng nghiên cứu: trẻ em từ 24-60 tháng tuổi tại 2 trường mầm non thuộc xã Nam Hồng, huyện Đông Anh. Nghiên cứu được chia làm 2 giai đoạn: giai đoạn 1: mô tả cắt ngang trên 1593 trẻ; giai đoạn 2: nghiên cứu bệnh chứng ghép cặp (1 trẻ suy dinh dưỡng/5 trẻ bình thường và 1 trẻ thừa cân béo phì/5 trẻ bình thường theo tuổi, giới, lớp). Kết quả nghiên cứu: Toàn mẫu tỷ lệ trẻ có tình trạng dinh dưỡng bình ...

  • Developing a list of important drug- drug interactions in the clinical practice in the internal department – Kien An Hospital, Hai Phong City .pdf.jpg
  • Article


  • Authors: Nguyen, Thi Hanh; Vu, Thi Phuong Thao; Ha, Quang Tuan; Nguyen, Xuan Bach; Nguyen, Thanh Hai (2019)

  • This study was aimed to develop a list of important drug- drug interactions (DDIs) at the Internal department – Kien An Hospital. Subjects and methods: This study was 3 phases: (1) The construction of the initiative list was based on consenous of the documentations from the list of drugs in Kien An hospital: Micromedex 2.0, the patient leaflets and Drug Interaction Fact 2014. (2) The research group reviewed all the in-patient medical records in the General internal department and Cardiology department and sorted the high-frequency DDIs with prevalance higher than 1%. (3) After the DDIs of the first list and the second list were assessed by a group of doctors and pharmacists who the pr...

  • Glomerular Filtration Rate Calculation Based on Serum Creatinin and Cystatin C in Type 2 Diabetic Patients .pdf.jpg
  • Article


  • Authors: Vu, Thi Thom; Vu, Van Nga; Do, Thi Quynh; Nguyen, Thi Binh Minh; Dinh, Thi My Dung; Le, Ngoc Thanh (2019)

  • The incidence of type 2 diabetes mellitus is rapidly increasing, with many complications pressured on the health care system. Complications of diabetes due to chronic hyperglycemia related to other metabolic disorders, causing damage to the microvascular system. Among them, damaged kidney vessels lead to impair the renal function as diabetic nephropathy is the most common cause of end-stage renal disease. Measurement of glomerular filtration rate (GFR) is an important parameter in assessing renal function. In Vietnam’s hospital, serum creatinine is the biomarker mostly used to assess GFR. However, this biomarker is affected many factors such as gender, age, ... Many studies showed tha...

  • Population Pharmacokinetics of Rifampicin on Pulmonary Tuberculosis Patients .pdf.jpg
  • Article


  • Authors: Bùi, Sơn Nhất; Vũ, Đình Hòa; Lê, Anh Tuấn; Lê, Thị Luyến (2019)

  • Mục tiêu nghiên cứu: Chúng tôi xác định các thông số và khảo sát các yếu tố liên quan tới dược động học quần thể của rifampicin trên bệnh nhân điều trị lao phổi theo mô hình ảnh hưởng hỗn hợp phi tuyến tính. Đối tượng và phương pháp: Gồm 120 bệnh nhân được chẩn đoán lao phổi mới hoặc tái trị, được điều trị tại 03 bệnh viện: Bệnh viện Phổi Hà Nội, Bệnh viện Phổi Trung ương và Bệnh viện K74. Bệnh nhân lao phổi được lấy mẫu vào ngày thứ 10 – 14 sau khi bắt đầu điều trị. Dữ liệu nồng độ - thời gian được xử lí trên phần mềm Monolix 2018. Kết quả: Mô hình phù hợp nhất là mô hình dược động học 1 ngăn, thể tích phân bố 33,5 L, độ thanh thải 9,62 L/h. Cân nặng trừ mỡ tính theo công thức của Ja...

Collection's Items (Sorted by Submit Date in Descending order): 1 to 20 of 103

Medical and Pharmaceutical Sciences : [103]

Follow this collection to receive daily e-mail notification of new additions
Collection's Items (Sorted by Submit Date in Descending order): 1 to 20 of 103
  • Validation of a High-Performance Liquid Chromatographic Method with Diod Array Detection for the Quantification of Citral and Formulation of Insect Repellent Cream from Lemongrass Oil.pdf.jpg
  • Article


  • Authors: Nguyen, Thi Thanh Binh; Bui, Thanh Tung; Nguyen, Thi Mai; Nguyen, Thi Hue (2020)

  • Lemongrass oil derived from some species of grasses in the family of Poaceae (particularly Cymbopogon citratus) posses a highly effective insect repellent potential. In Vietnam, this product is widely commercially available but its quality is not strictly controlled. From a formulator's perspective, lemongrass essential oil is not suitable for direct application on the skin because high concentrations of citral, major chemical constituent of this oil, may cause local irritation. In addition, this compound is volatile, resulting in a short repellent effect. Contributing to solve these problems, a high-performance liquid chromatography with diode array detection was developed for the si...

  • Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract.pdf.jpg
  • Article


  • Authors: Tran, Thi Hai Yen; Hoang, Thi Hien; Vu, Thi Thu Giang (2020)

  • Rutin is a natural flavonoid that has many effects on human health and beauty. However, rutin has low solubility and bioavailability. Niosomes are drug delivery system that enhance drug permeation of drug through the skin. Aloe is widly used in cosmetic preparations due to its antiaging, moisturizing and essential skin nutrients. Therefore, the aim of study is preparation of nano niosomes, loaded with rutin and aloe gel extraction (rutin-aloe niosomes) by thin film hydration method. Rutin niosomes was reduced size by ultrasonic method. The size and distribution of vesicles were determined by dynamic light scattering method. Drug content in niosomal suspension was determined by UV-Vis...

  • Malignant Hyperthermia and Gene Polymorphisms Related to Inhaled Anesthesia Drug Response.pdf.jpg
  • Article


  • Authors: Vu, Thi Thu Hang; Nguyen, Thi Thuy Mau; Nguyen, Tran Thuy; Le, Ngoc Thanh; Pham, Thi Hong Nhung; Dinh, Doan Long; Nguyen, Thi Thu Hoai; Vu, Thi Thom (2020)

  • Malignant hyperthermia (MH) is a clinical response happened to patient who is sensitive with inhaled anesthesia drug that could cause suddently death. Many previous studies showed that malignant hyperthermia strongly related to genetic background of patients including RYR1, CACNA1S or STAC3 gene polymorphisms. With the development of high technology such as next generation sequencing, scientists found that 37 to 86 percents of MH cases had RYR1 mutations and approximately 1 percent of those had CACNA1S mutations. Gene analysis testing was recommended to apply for patient with MH medical history or MH patient’s family relations.

  • Knowledge, Attitude of Parents’s and Quality of Life in Children with Chronic Kidney Disease.pdf.jpg
  • Article


  • Authors: Phan, Van Dem; Le, Thi Thu Hoai (2020)

  • To identify the percentage of parents having the correct knowledge of caring their children and evaluable quality of life in children with chronic kidney diseases. Subject and method: descriptive cross sectional study and evaluated the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales of 115 children with chronic kidney diseases (CKD) and their parents who treated at Department of Pediatric of Bach Mai hospital. Results: the parents’ correct knowledge about CKD was persistant and relapse (90,4% and 89,4%). The sourse of information parents’s from medical staffs was 48,2% and 23% from social networking. Over 50% of parents thought that knowledge getting from medical...

  • Jak-Stat Signaling Pathway Related Gene Expressions and Blood Biochemical indicators in Acute Promyelocytic Leukemia.pdf.jpg
  • Article


  • Authors: Bui, Kieu Trang; Nguyen, Thi Xuan (2020)

  • Acute promyelocytic leukemia (APL) is a type of acute leukemia, which has the highest death rate among blood cancers and caused by a specific (15; 17) chromosomal translocation, resulting in a fusion gene PML/RARα. Klotho gene plays a role in preventing aging, inflammation and cancer. CTLA4, PD1 and LAG3 are immunosuppressive receptors located on surface of T cells and considered as a negative regulation of immune response. These genes regulate immune cell activity through several signalling moleculars such as STATs and NF-κB. In this study, to additionally determine the difference between APL and other leukemia, we performed experiments to measure mRNA expression of above genes by us...

  • Henoch-Schonlein Purpura in Children at Department of Pediatric, Bach Mai Hospital.pdf.jpg
  • Article


  • Authors: Pham, Van Dem (2020)

  • Henoch-Schonlein Purpura (HSP) is one of the most common vasculitis disease in children. The main symtomps are rash, arthritis, abdominal pain, and kidney disease. In particular, kidney involvement is important to predict long-term outcomes of disease. Aim: This study aimed to describe the epidemic characteristics, clinical manifestations and some laboratory findings of HSP in children. Subjects of study: We studied 50 patients diagnosed with HSP at Deparment of Pediatrics, Bach Mai hospital from 2017 to 2018. Results: The mean age was 9,1 ± 3,2 years, with the ratio of male to female to be 1,17:1. HSP has seasonal characteristics, it was more common in the spring (43.4%) and the win...

  • Evaluation of the Usage of Erythropoietin in Patients with End-Stage Chronic Kidney Disease Dialysis Cycle in Hanoi Nephrology Hospital.pdf.jpg
  • Article


  • Authors: Do, Thi Hoa; Nguyen, Thi Tuyet Trinh; Nguyen, Thi Lien Huong; Phan, Tung Linh (2020)

  • Treatment and control of anemia plays an important role in improving the quality and effectiveness of artificial kidney. The study was conducted on 61 patients who met the selection and were not included in the excluded criteria group. Collecting data from medical records using retrospective, descriptive, vertical follow-up method for 6 months. Data were processed using Microsoft Excel Office 2010 and R. The results showed that patients used both EPO alpha and EPO beta simultaneously. Rate of usage’s EPO beta accounted for 23%, alpha EPO was 77%. Lyophilized form (EPO alpha) is most commonly used. Starting from T3, Hb. averages treat. There were no abnormalities in blood pressure, whi...

  • Cytotoxicity and Antioxidant Effects of Celastrus hindsii Benth. Leaf Extract.pdf.jpg
  • Article


  • Authors: Bui, Thi Thanh Duyen; Dang, Kim Thu; Vu, Manh Hung; Bui, Thanh Tung (2020)

  • Celastrus hindsii Benth et Hook. is known as a herbal medicine for the treatment of cancer. In this study we evaluated the cytotoxic and antioxidant effects of Celastrus hindsii Benth et Hook. leaf extract. Samples of Celastrus hindsii were extracted with 90 % ethanol and subsequently fractionated with n-hexane, ethyl acetate (EtOAc) and n-butanol (n-BuOH) solvents. To evaluate the cytotoxic effect, we performed MTT (3- (4,5 dimethylthiazol-2 - yl) - 2,5 - diphenyltetrazolium) assay on the three cell lines human liver Hep G2 (HB - 8065TM), lung LU-1 (HTB - 57TM), breast MCF-7 (HTB - 22TM). The antioxidant effect was evaluated by screening DPPH (2,2-diphenyl-1-picryhydrazyl) free radi...

  • Formulating Methyl Salicylate Microemulsion.pdf.jpg
  • Article


  • Authors: Tran, Thi Hai Yen; Hoang, Thuc Oanh; Vu, Thi Thu Giang (2020)

  • Methyl salicylate (MS) is an active pharmaceutical ingredient of NSAIDS group, often used in topical dosage forms such as ointments, gels, patches, etc. to treat and relieve muscle and joint diseases. Microemulsion is the potential drug delivery systems because of various advantages: oil droplet size is in range of several nanometers, good appearance, transparent, simple methods of preparation and simple application in manufacturing. The purpose of the study is to formulate a phase diagram to identify the area of methyl salicylate microemulsion formation and formulate MS microemulsion 1% and 5%. The water titration method is used to build the phase diagram. MS microemulsions were eval...

  • Evaluation of the Effect of Dissolution Conditions on the Release Profiles of Felodipine from the Extended Release Push-Pull Osmotic Tablets.pdf.jpg
  • Article


  • Authors: Vu, Thi Thanh Huyen; Nguyen, Thanh Hai; Pham, Thi Minh Hue (2020)

  • The bilayered push–pull osmotic tablets of 5 mg felodipine were prepared by the double compression method, then the core tablets were coated with cellulose acetate as a semipermeable membrane. One releasing orifice was drilled by laser on the drug side of tablets. The osmotic tablets of felodipine containing low molecular weight PEO (200.000) as the primary component in the drug layer, high molecular weight PEO (5.000.000) as a swelling agent in the push layer and natri chloride as osmotic agent in both drug and push layers which were semi-permeable membrane coated with a weight gain of 8.5 % and the drilled release orifice of 0.8 mm. The influence of dissolution conditions on the rele...

  • Comparing Acetylcholinesterase and Butyrylcholinesterase Inhibition Effect of Total Extract and Fractions with Alcaloid-Rich Extract of Huperzia Serrata (Thunb.) Trevis..pdf.jpg
  • Article


  • Authors: Nguyen, Thi Thu Hoai; Nguyen, Thuy Duong; Bui, Thanh Tung; Dao, Thi Vui; Dang, Kim Thu (2020)

  • Herbal extract, rich with natural compounds, has been used for medicinal purpose such as treating neurological disorders such as cognitive defection for a long period of time, often without significant adverse effects. We compared AChE and BuChE – inhibition effect of total extracts and fractions of Huperzia serrata (Thunb.) Trevis. with alcaloid-rich extract. Our samples were subjected under supersonic extraction with ethanol 50o as solvent and fractionally extracted with nhexane, EtOAc and n-butanol, respectively; alcaloid-rich extract was collected simutaneously. Ellman’s method was used to assay AChE and BuChE inhibition activity. Results: Alcaloid-rich extraction proved to be the...

  • Anatomy of the Middle Cerebral Artery and some related arteries on 256 MSCT .pdf.jpg
  • Article


  • Authors: Nguyễn, Tuấn Sơn; Ngô, Xuân Khoa; Nguyễn, Quốc Dũng; Đào, Đình Thi (2019)

  • Mục tiêu: Xác định tỷ lệ hiện ảnh và kích thước của động mạch (ĐM) não giữa và một số ĐM liên quan bằng hình ảnh phim chụp cắt lớp vi tính 256 dãy. Phương pháp: nghiên cứu mô tả cắt ngang hồi cứu với phương pháp chọn mẫu thuận tiện cỡ mẫu 261. Kết quả: Khả năng hiện ảnh các đoạn của ĐM não giữa là 100%; ĐM thông sau là 76,4; ĐM cảnh trong đoạn trong sọ ngoài màng cứng là 100%%; Đường kính trung bình (ĐKTB), chiều dài trung bình (CDTB) của các ĐM lần lượt là (mm): M1T 3,25±0,43 và 19,98±6,10; M1 P 3,26±0,46 và 19,68±6,28; M2T trái 2,10±0,48 và 22,85±13,18; M2T phải 2,09±0,49 và 23,42±11,89; M2D trái 2,48±0,49 và 31,73-16,36; M2D phải 2,55±0,49 và 29,11±15,31. PCoA T 1,29±0,63 và 11,87±...

  • Direct costs for treatment of venous thromboembolism complication 90-day after surgery .pdf.jpg
  • Article


  • Authors: Bùi, Mỹ Hạnh; Dương, Tuấn Đức; Trần, Tiến Hưng; Nguyễn, Hữu Chính; Kiều, Thị Tuyết Mai (2019)

  • Study object: Describe the direct treatment costs due to venous thromboembolism complications 90 days after surgery by using national health insurance reimbursement database. Patients: 824,947 adult patients who underwent major surgeries were enrolled from January 1, 2017 to September 31, 2018. Method: Study was conducted by using cross-sectional descriptive design. Patients were considered VTE case if they had a diagnostic code up to 90 days after the first surgery, thus 1472 were diagnosed as having VTE after surgery. The study using propensity score matching method shows that there were 913 pairs of patients with the same propensity score included in analysis. Results: The rate of ...

  • Analysis of cots for children treatment pneumonia in Bach Mai Ha Noi hospital from 102018 to 32019 .pdf.jpg
  • Article


  • Authors: Bùi, Thị Xuân; Phạm, Văn Đếm; Hoàng, Văn Hùng (2019)

  • Nghiên cứu chi phí trực tiếp điều trị viêm phổi trẻ em điều trị ở bệnh viện Bạch Mai từ tháng 10/2018 đến tháng 3/2019 cho thấy chi phí giường bệnh chiếm tỷ lệ cao nhất, sau đó mới đến chi phí thuốc và chi phí cho chẩn đoán.Trong chi phí thuốc thì kháng sinh là cao nhất, trong chi phí chẩn đoán thì chi phí xét nghiệm chiếm chủ yếu. Chi phí điều trị có mối liên quan rõ rệt đến số ngày điều trị bên cạnh đó các yếu tố mức độ bệnh hay có bệnh mắc kèm chỉ ảnh hưởng khi xem xét riêng lẻ. Sự hỗ trợ của bảo hiểm y tế có thể lên tới hơn 70% tổng chi phí trực tiếp. Kết quả nghiên cứu cho thấy chi phí điều trị ở Việt Nam thấp hơn một số nước trong khu vực, sự phân bổ chí phí tương đồng với một s...

  • Diagnosis of Left Ventricular Hypertrophy Based on Electrocardiogram Signal and Fuzzy Logic .pdf.jpg
  • Article


  • Authors: Trần, Như Chí; Nguyễn, Thị Thanh Vân; Lê, Văn Chiều (2019)

  • Chỉ số Sokolow – Lyon dùng để xác định bệnh phì đại thất trái từ Điện tâm đồ (ECG) là một chỉ số giới hạn cứng. Bởi vậy, biểu hiện lâm sàng của bệnh có thể bị bỏ qua khi giá trị tính được là lân cận ngưỡng. Một vài nghiên cứu đã đề xuất kết hợp nhiều chỉ số khác nhau để cải tiến chất lượng chẩn đoán bệnh. Tuy nhiên, quá trình kiểm tra và chẩn đoán sẽ mất nhiều thời gian do cần thu thập dữ liệu lớn. Để giải quyết vấn đề này, báo cáo đề xuất một phương pháp chẩn đoán lâm sàng bệnh phì đại thất trái sử dụng kỹ thuật Logic mờ kết hợp xử lý tín hiệu số. Phương pháp đề xuất chủ yếu sử dụng chỉ số Sokolow – Lyon (SV1+RV5/V6 ≥ 35 mm) để phát hiện những dấu hiệu bất thường của tín hiệu ECG như...

  • APOC3-rs2854116 polymorphism related to hypercholesterolemia in primary school children in Hanoi .pdf.jpg
  • Article


  • Authors: Nguyễn, Thị Hồng Hạnh; Trần, Quang Bình (2019)

  • Gen Apolipoprotein C3 (APOC3) giữ vai trò quan trọng trong việc điều chỉnh nồng độ lipid của cơ thể. Nghiên cứu này được tiến hành nhằm đánh giá mối liên quan của đa hình APOC3-rs2854116 với rối loạn lipid máu (RLLM) ở trẻ tiểu học tại Hà Nội. Một nghiên cứu bệnh - chứng được tiến hành trên 161 trẻ mắc RLLM và 406 trẻ bình thường từ 6 - 11 tuổi. Kiểu gen được xác định bằng phương pháp đa hình chiều dài đoạn cắt giới hạn (PCR-RFLP). Kết quả cho thấy, ở nhóm bệnh, có sự khác nhau về các chỉ số lipid máu giữa những trẻ mang kiểu gen khác nhau tại đa hình APOC3-rs2854116. Trẻ mang kiểu gen G/G có nồng độ cholesterol tổng số (TC), triglyceride (TG) và lipoprotein tỉ trọng thấp (Low Density...

  • Double Burden of Nutrition and some Eating Habits Characteristics of Preschool Children in Nam Hong Commune, Dong Anh district, Hanoi, 2018 .pdf.jpg
  • Article


  • Authors: Lê, Thị Tuyết; Nguyễn, Thị Trung Thu; Ngô, Thị Thu Hoài; Nguyễn, Thị Lan Hương; Lê, Thị Thùy Dung; Đỗ, Nam Khánh (2019)

  • Nghiên cứu nhằm cung cấp bằng chứng về gánh nặng kép dinh dưỡng (bao gồm cả suy dinh dưỡng (SDD) và thừa cân, béo phì (TC, BP)) cũng như ảnh hưởng của thói quen ăn uống đến tình trạng dinh dưỡng của trẻ mầm non xã Nam Hồng, huyện Đông Anh, Hà Nội - nơi đang trong quá trình đô thị hóa. Đối tượng nghiên cứu: trẻ em từ 24-60 tháng tuổi tại 2 trường mầm non thuộc xã Nam Hồng, huyện Đông Anh. Nghiên cứu được chia làm 2 giai đoạn: giai đoạn 1: mô tả cắt ngang trên 1593 trẻ; giai đoạn 2: nghiên cứu bệnh chứng ghép cặp (1 trẻ suy dinh dưỡng/5 trẻ bình thường và 1 trẻ thừa cân béo phì/5 trẻ bình thường theo tuổi, giới, lớp). Kết quả nghiên cứu: Toàn mẫu tỷ lệ trẻ có tình trạng dinh dưỡng bình ...

  • Developing a list of important drug- drug interactions in the clinical practice in the internal department – Kien An Hospital, Hai Phong City .pdf.jpg
  • Article


  • Authors: Nguyen, Thi Hanh; Vu, Thi Phuong Thao; Ha, Quang Tuan; Nguyen, Xuan Bach; Nguyen, Thanh Hai (2019)

  • This study was aimed to develop a list of important drug- drug interactions (DDIs) at the Internal department – Kien An Hospital. Subjects and methods: This study was 3 phases: (1) The construction of the initiative list was based on consenous of the documentations from the list of drugs in Kien An hospital: Micromedex 2.0, the patient leaflets and Drug Interaction Fact 2014. (2) The research group reviewed all the in-patient medical records in the General internal department and Cardiology department and sorted the high-frequency DDIs with prevalance higher than 1%. (3) After the DDIs of the first list and the second list were assessed by a group of doctors and pharmacists who the pr...

  • Glomerular Filtration Rate Calculation Based on Serum Creatinin and Cystatin C in Type 2 Diabetic Patients .pdf.jpg
  • Article


  • Authors: Vu, Thi Thom; Vu, Van Nga; Do, Thi Quynh; Nguyen, Thi Binh Minh; Dinh, Thi My Dung; Le, Ngoc Thanh (2019)

  • The incidence of type 2 diabetes mellitus is rapidly increasing, with many complications pressured on the health care system. Complications of diabetes due to chronic hyperglycemia related to other metabolic disorders, causing damage to the microvascular system. Among them, damaged kidney vessels lead to impair the renal function as diabetic nephropathy is the most common cause of end-stage renal disease. Measurement of glomerular filtration rate (GFR) is an important parameter in assessing renal function. In Vietnam’s hospital, serum creatinine is the biomarker mostly used to assess GFR. However, this biomarker is affected many factors such as gender, age, ... Many studies showed tha...

  • Population Pharmacokinetics of Rifampicin on Pulmonary Tuberculosis Patients .pdf.jpg
  • Article


  • Authors: Bùi, Sơn Nhất; Vũ, Đình Hòa; Lê, Anh Tuấn; Lê, Thị Luyến (2019)

  • Mục tiêu nghiên cứu: Chúng tôi xác định các thông số và khảo sát các yếu tố liên quan tới dược động học quần thể của rifampicin trên bệnh nhân điều trị lao phổi theo mô hình ảnh hưởng hỗn hợp phi tuyến tính. Đối tượng và phương pháp: Gồm 120 bệnh nhân được chẩn đoán lao phổi mới hoặc tái trị, được điều trị tại 03 bệnh viện: Bệnh viện Phổi Hà Nội, Bệnh viện Phổi Trung ương và Bệnh viện K74. Bệnh nhân lao phổi được lấy mẫu vào ngày thứ 10 – 14 sau khi bắt đầu điều trị. Dữ liệu nồng độ - thời gian được xử lí trên phần mềm Monolix 2018. Kết quả: Mô hình phù hợp nhất là mô hình dược động học 1 ngăn, thể tích phân bố 33,5 L, độ thanh thải 9,62 L/h. Cân nặng trừ mỡ tính theo công thức của Ja...

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